(4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol

Base Information Edit

Chemical Name:(4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol
CAS No.:1052661-31-0
Molecular Formula:C₅₀H₈₀O₇Si₂
Molecular Weight:849.352
Hs Code.:
Mol file:1052661-31-0.mol

(4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol

Synonyms:(4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol

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Chemical Property of (4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol Edit

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Technology Process of (4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol

There total 2 articles about (4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1052661-29-6
(4R,6E,9S,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-one

: 1052661-31-0
(4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -90 ℃; for 1.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol801493w

Reference yield:

: 1018689-59-2
(R,E)-1-iodo-4-(methoxymethoxy)-2-methylhept-1-ene

: 529510-42-7
(2S,3S,5R)-3-(tert-Butyldimethylsiloxy)-9-(tert-butyldiphenylsiloxy)-5-(4-methoxybenzyloxy)-2-methylnonanal

: 1052661-31-0
(4R,6E,8R,9R,10S,12R)-10-(tert-butyldimethylsiloxy)-16-(tert-butyldiphenylsiloxy)-12-(4-methoxybenzyloxy)-4-methoxymethoxy-6,9-dimethylhexadec-6-en-8-ol

: 1052661-28-5
C₅₀H₈₀O₇Si₂

Guidance literature:: (R,E)-1-iodo-4-(methoxymethoxy)-2-methylhept-1-ene; With tert.-butyl lithium; In diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

(2S,3S,5R)-3-(tert-Butyldimethylsiloxy)-9-(tert-butyldiphenylsiloxy)-5-(4-methoxybenzyloxy)-2-methylnonanal; In diethyl ether; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol801493w