529510-42-7Relevant articles and documents
Ruthenium-SYNPHOS-catalyzed asymmetric hydrogenations: an entry to highly stereoselective synthesis of the C15-C30 subunit of dolabelide A
Roche, Christophe,Desroy, Nicolas,Haddad, Mansour,Phansavath, Phannarath,Genet, Jean-Pierre
supporting information; experimental part, p. 3911 - 3914 (2009/07/01)
(Chemical Equation Presented) An efficient construction of the C15-C30 segment of the cytotoxic macrolide dolabelide A is described. The synthesis relies on ruthenium-SYNPHOS-mediated asymmetric hydrogenation reactions of β-keto esters to generate the C19, C21, and C27 hydroxyl-bearing stereocenters with very high levels of enantio- and diastereoselectivity.