4-Chloro-2-fluoro-5-iodotoluene

Base Information

Chemical Name:4-Chloro-2-fluoro-5-iodotoluene
CAS No.:202982-69-2
Molecular Formula:C7H5 Cl F I
Molecular Weight:270.47
Hs Code.:2903998090
DSSTox Substance ID:DTXSID00378615
Wikidata:Q82168094
Mol file:202982-69-2.mol

Synonyms:202982-69-2;4-Chloro-2-fluoro-5-iodotoluene;1-chloro-5-fluoro-2-iodo-4-methylbenzene;Benzene, 1-chloro-5-fluoro-2-iodo-4-methyl-;DTXSID00378615;MFCD00143281;AKOS016846170;EN300-3526402;A814411

Suppliers and Price of 4-Chloro-2-fluoro-5-iodotoluene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-Chloro-5-fluoro-2-iodo-4-methylbenzene 95+%
5g
$ 662.00

American Custom Chemicals Corporation
4-CHLORO-2-FLUORO-5-IODOTOLUENE 95.00%
5MG
$ 505.26

Alichem
4-Chloro-2-fluoro-5-iodotoluene
500mg
$ 790.55

Alichem
4-Chloro-2-fluoro-5-iodotoluene
250mg
$ 480.00

Total 9 raw suppliers

Chemical Property of 4-Chloro-2-fluoro-5-iodotoluene

Chemical Property:

Vapor Pressure:0.0509mmHg at 25°C
Refractive Index:1.594
Boiling Point:243.1°Cat760mmHg
Flash Point:100.9°C
PSA：0.00000
Density:1.879g/cm³
LogP:3.39210
Storage Temp.:2-8°C
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:269.91085
Heavy Atom Count:10
Complexity:120

Purity/Quality:

97% ^*data from raw suppliers

1-Chloro-5-fluoro-2-iodo-4-methylbenzene 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1F)Cl)I

Technology Process of 4-Chloro-2-fluoro-5-iodotoluene

There total 1 articles about 4-Chloro-2-fluoro-5-iodotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 452-75-5
4-chloro-2-fluorotoluene

: 202982-69-2
1-chloro-5-fluoro-2-iodo-4-methylbenzene

Guidance literature:: With N-iodo-succinimide; In trifluoroacetic acid; at 25 ℃; for 12h;
DOI:10.1081/NCN-100001435

Reference yield:

: 169526-37-8
(6aR,9aS)-2,2,4,4-tetraisopropyltetrahydro-8H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-one

: 202982-69-2
1-chloro-5-fluoro-2-iodo-4-methylbenzene

: 3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1,2-dideoxy-1-(2-chloro-4-fluoro-5-methylphenyl)-β-D-ribofuranose

Guidance literature:: 1-chloro-5-fluoro-2-iodo-4-methylbenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(6aR,9aS)-2,2,4,4-tetraisopropyltetrahydro-8H-furo[3,2-f ][1,3,5,2,4]trioxadisilocin-8-one; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 3h;
DOI:10.1002/anie.200504296

Reference yield:

: 202982-69-2
1-chloro-5-fluoro-2-iodo-4-methylbenzene

: 333447-71-5
1,2-dideoxy-1-(2-chloro-4-fluoro-5-methylphenyl)-β-D-ribofuranose

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: tetrahydrofuran; hexane / 1 h / -78 °C

1.3: triethylsilane; BF₃*OEt₂ / CH₂Cl₂ / 3 h / -78 °C

2.1: Bu₄NF / tetrahydrofuran / 2 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane;
DOI:10.1002/anie.200504296