452-75-5

Usage

Chemical Properties

colorless to light yellow liquid

Uses

4-Chloro-2-fluorotoluene has been used in the preparation of 4-chloro-2-fluoro-benzylbromide.

General Description

Fourier Transform (FT)-IR and FT-Raman spectra of solid sample of 4-chloro-2-fluorotoluene have been studied.

InChI:InChI=1/C7H6F2/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3

Upstream product

• 1063716-83-5 Pd(C₅H₅N)(C₁₃H₈N₂SO₂C₆H₄NO₂)(C₆H₃ClCH₃) 
• 148839-33-2 (5-chloro-2-methylphenyl)boronic acid 

Downstream Products

• 148627-75-2 4-(3-fluoro-4-methylphenyl)pyridine 
• 71916-82-0 1-(bromomethyl)-4-chloro-2-fluorobenzene 
• 181827-49-6 1-(2-chloro-4-fluoro-5-methylphenyl)ethan-1-one 
• 202982-69-2 1-chloro-5-fluoro-2-iodo-4-methylbenzene 
• 333447-71-5 1,2-dideoxy-1-(2-chloro-4-fluoro-5-methylphenyl)-β-D-ribofuranose 
• 333447-55-5 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-4-chloro-2-fluorotoluene 
• 333447-54-4 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-4-chloro-2-fluorotoluene 
• 369-32-4 1-(4-fluoro-3-methylphenyl)ethanone 
• 345-66-4 (4-fluoro-3-methylphenyl)(phenyl)methanone 
• 61072-56-8 4-chloro-2-fluorobenzaldehyde 
• 87073-75-4 4-Chloro-2-dimethylaminobenzaldehyde 
• 754944-16-6 (S)-4-Chloro-2-fluorophenylalanine 
• 185826-38-4 (2S,5S)-1-(tert-Butyloxycarbonyl)-2-(tert-butyl)-3-methyl-5-(4'-chloro-2'-fluorobenzyl)-1,3-imidazolidine-4-one 

Relevant academic research and scientific papers

SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS

Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes. Also described herein are compositions and kits containing compounds and palladium complexes described herein.

Palladium-mediated fluorination of arylboronic acids

(Chemical Equation Presented) Saving the best for last: Novel palladium complexes allow mild, two-step fluorination of aryl boronic acids (see scheme). The reaction is regiospecific, functional-group tolerant, has a broad substrate scope, and is ideally suited for the introduction of fluorine substituents at a late stage for aryl fluoride synthesis.