(3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile

Base Information

Chemical Name:(3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile
CAS No.:910028-65-8
Molecular Formula:C₁₇H₂₅Cl₂NO₂Si
Molecular Weight:374.383
Hs Code.:

Synonyms:(3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile

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Technology Process of (3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile

There total 1 articles about (3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78906-15-7,114413-26-2,124150-87-4,123237-62-7
tert-butyldimethylsilyl (S)-glycidyl ether

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 910028-65-8
(3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile

Guidance literature:: With n-butyllithium; boron trifluoride-tetrahydrofuran complex; In tetrahydrofuran; hexane; at -78 - -25 ℃;
DOI:10.1021/ol061650w

Reference yield:

: 910028-65-8
(3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile

: 910028-22-7
(1R,2S)-1-(3,4-dichlorophenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: DABCO / ethyl acetate / 1 h / 20 °C

2: t-BuOK; DMPU / tetrahydrofuran / 1 h

3: aq. TBAF / tetrahydrofuran

With 1,4-diaza-bicyclo[2.2.2]octane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/ol061650w

Reference yield:

: 910028-65-8
(3S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3,4-dichlorophenyl)-3-hydroxybutanenitrile

: (1S,2S)-1-(3,4-Dichloro-phenyl)-2-hydroxymethyl-cyclopropanecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: DABCO / ethyl acetate / 1 h / 20 °C

2: t-BuOK; DMPU / tetrahydrofuran / 1 h

3: aq. TBAF / tetrahydrofuran

With 1,4-diaza-bicyclo[2.2.2]octane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/ol061650w