(R)-(-)-N,S-DIMETHYL-S-PHENYLSULPHOXIMINE

Base Information

• Chemical Name: (R)-(-)-N,S-DIMETHYL-S-PHENYLSULPHOXIMINE
• CAS No.: 20414-85-1
• Molecular Formula: C8H11 N O S
• Molecular Weight: 169.247
• Hs Code.: 2925290090
• Mol file: 20414-85-1.mol

Synonyms:Sulfoximine,S-methyl-S-(4-methylphenyl)-, (R)-; Sulfoximine, S-methyl-S-p-tolyl-, (R)-(-)-(8CI); (R)-(-)-Methyl p-tolyl sulfoximine

Chemical Property of (R)-(-)-N,S-DIMETHYL-S-PHENYLSULPHOXIMINE

Chemical Property:

• Vapor Pressure: 0.0117mmHg at 25°C
• Refractive Index: n20/D 1.565(lit.)
• Boiling Point: 269.8°Cat760mmHg
• Flash Point: 117°C
• PSA: 37.81000
• Density: 1.06g/cm³
• LogP: 2.63880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(-)-N,S-DIMETHYL-S-PHENYLSULPHOXIMINE

There total 25 articles about (R)-(-)-N,S-DIMETHYL-S-PHENYLSULPHOXIMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Methyl p-tolyl sulfoxide (934-72-5) → S-methyl-S-(p-tolyl)sulfoximine (20414-85-1,22132-97-4,52720-03-3,121123-21-5)

Guidance literature:

With [bis(acetoxy)iodo]benzene; ammonium carbamate; In methanol; at 25 ℃; for 1h; Reagent/catalyst; Temperature; Solvent; Concentration;

DOI:10.1055/s-0036-1590874

Reference yield: 98.0%

tert-butyl[methyl(4-methylphenyl)oxido-λ6-sulfanylidene]carbamate → S-methyl-S-(p-tolyl)sulfoximine (20414-85-1,22132-97-4,52720-03-3,121123-21-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.5b00844

Reference yield: 96.0%

4-methylphenyl methylsulfide (623-13-2) → S-methyl-S-(p-tolyl)sulfoximine (20414-85-1,22132-97-4,52720-03-3,121123-21-5)

Guidance literature:

With [bis(acetoxy)iodo]benzene; ammonium carbamate; In methanol; at 25 ℃; for 3h; Reagent/catalyst; Solvent; chemoselective reaction;

DOI:10.1039/c6cc08891k

upstream raw materials:

(R)-methyl p-tolyl sulfoxide

(R)-S-methyl-S-(4-tolyl)-N-(p-tolylsulfonyl)sulfoximine

C₁₉H₂₉NO₃S

4-methylbenzenesulfinyl chloride

Downstream raw materials:

C₁₀H₁₄N₂O₂S

N-(N'-butyl-carbamoyl)-methyl-(4-tolyl)-sulfoxim

Methyl p-tolyl sulfoxide

C₈H₁₀N₂O₃S

Refernces

• 1、 Rayner,D.R. et al.. "-". . p. 2721 - 2723. Retrieved 1968.
• 2、 Zhou, Tao,Qian, Pu-Fan,Li, Jun-Yi,Zhou, Yi-Bo,Li, Hao-Chen,Chen, Hao-Yu,Shi, Bing-Feng. "Efficient Synthesis of Sulfur-Stereogenic Sulfoximines via Ru(II)-Catalyzed Enantioselective C-H Functionalization Enabled by Chiral Carboxylic Acid". supporting information. p. 6810 - 6816. Retrieved 2021/05/29.
• 3、 Amri, Nasser,Wirth, Thomas. "Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes". . p. 15961 - 15972. Retrieved 2021/07/20.