623-13-2 Usage
Description
(4-Methylthio)toluene, also known as Methyl p-Tolyl Sulfide (CAS# 623-13-2), is a clear colorless to light yellow liquid with unique chemical properties. It is formed through the aerobic oxidation process, catalyzed by a heteroscorpionate Ru(II)-aqua complex, and has been reported in the chloroperoxidase-catalyzed oxidation as well. This organic compound is known for its potential applications in various industries due to its distinct characteristics.
Uses
Used in Pharmaceutical Industry:
(4-Methylthio)toluene is used as a mediator for drug interaction in the context of polymorphic flavin-containing monooxygenase 3 in human livers. This application is significant as it aids in understanding and managing drug metabolism and interactions, ultimately contributing to the development of more effective and safer medications.
Used in Analytical Chemistry:
In the field of analytical chemistry, (4-Methylthio)toluene serves as a crucial component for analyzing peroxide in laundry detergents. The use of liquid chromatography in this process highlights the compound's role in ensuring the quality and safety of consumer products.
Used in Environmental Science:
The aerobic oxidation of (4-Methylthio)toluene, catalyzed by a heteroscorpionate Ru(II)-aqua complex, is an essential process in environmental science. This reaction helps in the degradation and detoxification of certain pollutants, contributing to a cleaner and healthier environment.
Used in Chemical Research:
The chloroperoxidase-catalyzed oxidation of (4-Methylthio)toluene is a significant area of study in chemical research. Understanding the mechanisms and outcomes of this reaction can lead to the development of new catalysts and processes, further advancing the field of chemistry and its applications.
Synthesis Reference(s)
Synthesis, p. 890, 1981 DOI: 10.1055/s-1981-29635
Check Digit Verification of cas no
The CAS Registry Mumber 623-13-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 3 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 623-13:
(5*6)+(4*2)+(3*3)+(2*1)+(1*3)=52
52 % 10 = 2
So 623-13-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H10S/c1-7-3-5-8(9-2)6-4-7/h3-6H,1-2H3
623-13-2Relevant articles and documents
Synthesis of Aryl Methyl Sulfides from Arysulfonyl Chlorides with Dimethyl Carbonate as the Solvent and C1 Source
Miao, Ren-Guan,Qi, Xinxin,Wu, Xiao-Feng
supporting information, p. 5219 - 5221 (2021/10/19)
A new procedure for the synthesis of aryl methyl sulfides from dimethyl carbonate (DMC) and arylsulfonyl chlorides has been achieved. In this strategy, DMC plays a dual role as both, C1 building block and green solvent. Arylsulfonyl chlorides served as the sulfur precursors, and a variety of aryl methyl sulfides were obtained in moderate to excellent yields with good functional group tolerance. Additionally, alkylsulfonyl chloride and dibenzyl carbonate are proven to be suitable substrates as well.
Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers
Delcaillau, Tristan,Boehm, Philip,Morandi, Bill
supporting information, p. 3723 - 3728 (2021/04/07)
We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis.
N-bromosuccinimide/HCl mediated reduction of sulfoxides to sulfides
Wang, Jianqiang,Shi, Fangmin,Dai, Dongyan,Xiong, Liping,Yang, Yongpo
supporting information, p. 439 - 443 (2021/02/03)
An efficient reduction of sulfoxides to sulfides mediated by N-bromosuccinimide (NBS)/HCl system has been developed. This protocol shows good functional group compatibility as well as broad substrates scope with operational simplicity.