6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one

Base Information

• Chemical Name: 6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one
• CAS No.: 797805-23-3
• Molecular Formula: C₄₁H₆₄N₄O₄
• Molecular Weight: 676.984
• Mol file: 797805-23-3.mol

Synonyms:6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one

Chemical Property of 6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one

There total 5 articles about 6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-[(E)-2-Methoxy-benzylimino]-1-{4-[3-(1-{6-[(E)-2-methoxy-benzylimino]-hexanoyl}-piperidin-4-yl)-propyl]-piperidin-1-yl}-hexan-1-one → 6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one (797805-23-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 6h;

DOI:10.1021/jm0494366

Reference yield:

6-(benzyloxycarbonylamino)hexanoic acid (1947-00-8) → 6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one (797805-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethyl chloroformate; Et₃N / dioxane / 0.5 h

1.2: 23 percent / dioxane / 72 h / 20 °C

2.1: 100 percent / HBr; AcOH / 4 h / 20 °C

3.1: toluene / 6 h / Heating

4.1: NaBH₄ / ethanol / 6 h / 20 °C

With sodium tetrahydroborate; hydrogen bromide; chloroformic acid ethyl ester; acetic acid; triethylamine; In 1,4-dioxane; ethanol; toluene;

DOI:10.1021/jm0494366

Reference yield:

1,3-di(piperidin-4-yl)propane (16898-52-5) → 6-(2-methoxybenzylamino)-1-[4-(3-{1-[6-(2-methoxybenzylamino)hexanoyl]piperidin-4-yl}propyl)piperidin-1-yl]hexan-1-one (797805-23-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethyl chloroformate; Et₃N / dioxane / 0.5 h

1.2: 23 percent / dioxane / 72 h / 20 °C

2.1: 100 percent / HBr; AcOH / 4 h / 20 °C

3.1: toluene / 6 h / Heating

4.1: NaBH₄ / ethanol / 6 h / 20 °C

With sodium tetrahydroborate; hydrogen bromide; chloroformic acid ethyl ester; acetic acid; triethylamine; In 1,4-dioxane; ethanol; toluene;

DOI:10.1021/jm0494366

upstream raw materials:

6-(benzyloxycarbonylamino)hexanoic acid

1,3-di(piperidin-4-yl)propane

6-amino-1-(4-{3-[1-(6-aminohexanoyl)piperidin-4-yl]propyl}piperidin-1-yl)hexan-1-one

[6-(4-{3-[1-(6-benzyloxycarbonylaminohexanoyl)piperidin-4-yl]propyl}piperidin-1-yl)-6-oxohexyl]carbamic acid benzyl ester