1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane

Base Information

• Chemical Name: 1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane
• CAS No.: 1370793-50-2
• Molecular Formula: C₅₃H₆₉N₆P₃
• Molecular Weight: 883.092
• Mol file: 1370793-50-2.mol

Synonyms:1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane

Chemical Property of 1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane

There total 2 articles about 1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

1,3-dichloro-2-(chloromethyl)-2-methylpropane (1067-09-0) + bis-(4-dimethylaminophenyl)phosphine (1769-51-3) → 1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane (1370793-50-2)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 130 - 140 ℃; Inert atmosphere;

DOI:10.1039/c2cc17832j

Reference yield:

4-bromo-N,N-dimethylaniline (586-77-6) → 1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane (1370793-50-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iodine; magnesium / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere; Reflux

2.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere

3.1: potassium tert-butylate / dimethyl sulfoxide / 130 - 140 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium tert-butylate; iodine; magnesium; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;

DOI:10.1039/c2cc17832j

Reference yield:

1,1,1-tris{[bis(4-dimethylaminophenyl)phosphino]methyl}ethane (1370793-50-2) + silver(I) 4-methylbenzenesulfonate (16836-95-6) → 6Ag(1+)*4CH3C(CH2P((C6H4)N(CH3)2)2)3*6CH3(C6H4)SO3(1-) = [Ag6(CH3C(CH2P((C6H4)N(CH3)2)2)3)4(C7H7SO3)3](C7H7SO3)3

Guidance literature:

In chloroform-d1; acetonitrile; triphosphine and Ag salt (molar ratio = 4:6) in CDCl3/CH3CN (4/1); crystn. by vapour diffusion of C6H6; XRD, NMR;

DOI:10.1039/c2cc17832j

upstream raw materials:

1,3-dichloro-2-(chloromethyl)-2-methylpropane

bis-(4-dimethylaminophenyl)phosphine

4-bromo-N,N-dimethylaniline