(2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester

Base Information

Chemical Name:(2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester
CAS No.:120230-43-5
Molecular Formula:C₂₉H₃₁NO₄
Molecular Weight:457.569
Hs Code.:

Synonyms:(2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester

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Chemical Property of (2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester

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Technology Process of (2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester

There total 3 articles about (2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 71432-55-8
2-tert-butyl-1,3-diisopropylisourea

: 349148-54-5
(2S,3R)-2-Methyl-3-(9-phenyl-9H-fluoren-9-ylamino)-succinic acid 1-methyl ester

: 120230-43-5
(2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester

Guidance literature:: In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/jo0014055

Reference yield:

: 55135-66-5
9-bromo-9-phenyl-9H-fluorene

: 120230-43-5
(2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMSCl / CHCl₃ / 2 h

1.2: 67 percent / Et₃N; Pb(NO₃)2 / CHCl₃ / 72 h

2.1: 73 percent / CH₂Cl₂ / 48 h / 20 °C

With chloro-trimethyl-silane; In dichloromethane; chloroform;
DOI:10.1021/jo0014055

Reference yield:

: (2S,3R)-2-amino-4-methoxy-3-methyl-4-oxobutanoic acid

: 120230-43-5
(2S,3R)-N-(9-phenylfluoren-9-yl)-3-methyl-aspartic acid 1-tert-butyl 4-methyl diester

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMSCl / CHCl₃ / 2 h

1.2: 67 percent / Et₃N; Pb(NO₃)2 / CHCl₃ / 72 h

2.1: 73 percent / CH₂Cl₂ / 48 h / 20 °C

With chloro-trimethyl-silane; In dichloromethane; chloroform;
DOI:10.1021/jo0014055