(E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal

Base Information

Chemical Name:(E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal
CAS No.:169898-11-7
Molecular Formula:C₂₀H₃₂O₃Si
Molecular Weight:348.558
Hs Code.:

Synonyms:(E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal

Suppliers and Price of (E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal

There total 7 articles about (E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 169898-10-6
((E)-(S)-4-Benzyloxy-3-methyl-hepta-2,6-dienyloxy)-tert-butyl-dimethyl-silane

: 169898-11-7
(E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal

Guidance literature:: ((E)-(S)-4-Benzyloxy-3-methyl-hepta-2,6-dienyloxy)-tert-butyl-dimethyl-silane; With ozone; In dichloromethane; at -78 ℃; for 0.166667h;

With triphenylphosphine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/jo034011x

Reference yield:

: 102191-92-4
tert-butyldimethylsiloxyacetaldehyde

: 169898-11-7
(E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal

Guidance literature:: Multi-step reaction with 5 steps

1.1: 84 percent / benzene / 48 h / 0 - 20 °C

2.1: diisopropylamine; n-BuLi / tetrahydrofuran / 1 h / -78 °C

2.2: 78 percent / tetrahydrofuran / 0.08 h

3.1: (-)-diisopropyl tartrate; Ti(O-iPr)4; tert-butylhydroperoxide / molecular sieves 3 Angstroem / CH₂Cl₂ / 20 h / -20 °C

3.2: 40 percent / FeSO₄; citric acid / H₂O; CH₂Cl₂

4.1: 76 percent / TfOH

5.1: DIBAL-H

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; (-)-diisopropyl tartrate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; diisopropylamine; 3 A molecular sieve; In tetrahydrofuran; dichloromethane; benzene; 1.1: Wittig olefination;
DOI:10.1021/jo034011x

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 169898-11-7
(E)-(S)-3-Benzyloxy-6-(tert-butyl-dimethyl-silanyloxy)-4-methyl-hex-4-enal

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 100 percent / PPh₃ / CH₂Cl₂ / -78 - 20 °C

3.1: 84 percent / benzene / 48 h / 0 - 20 °C

4.1: diisopropylamine; n-BuLi / tetrahydrofuran / 1 h / -78 °C

4.2: 78 percent / tetrahydrofuran / 0.08 h

5.1: (-)-diisopropyl tartrate; Ti(O-iPr)4; tert-butylhydroperoxide / molecular sieves 3 Angstroem / CH₂Cl₂ / 20 h / -20 °C

5.2: 40 percent / FeSO₄; citric acid / H₂O; CH₂Cl₂

6.1: 76 percent / TfOH

7.1: DIBAL-H

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; n-butyllithium; (-)-diisopropyl tartrate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; ozone; diisopropylamine; 3 A molecular sieve; In tetrahydrofuran; dichloromethane; benzene; 3.1: Wittig olefination;
DOI:10.1021/jo034011x