2-[(2-Chloro-acetyl)-methyl-amino]-2-(2-methoxycarbonyl-phenylazo)-malonic acid dimethyl ester

Base Information

Chemical Name:2-[(2-Chloro-acetyl)-methyl-amino]-2-(2-methoxycarbonyl-phenylazo)-malonic acid dimethyl ester
CAS No.:131843-83-9
Molecular Formula:C₁₆H₁₈ClN₃O₇
Molecular Weight:399.788
Hs Code.:

Synonyms:2-[(2-Chloro-acetyl)-methyl-amino]-2-(2-methoxycarbonyl-phenylazo)-malonic acid dimethyl ester

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Chemical Property of 2-[(2-Chloro-acetyl)-methyl-amino]-2-(2-methoxycarbonyl-phenylazo)-malonic acid dimethyl ester

Chemical Property:

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Technology Process of 2-[(2-Chloro-acetyl)-methyl-amino]-2-(2-methoxycarbonyl-phenylazo)-malonic acid dimethyl ester

There total 3 articles about 2-[(2-Chloro-acetyl)-methyl-amino]-2-(2-methoxycarbonyl-phenylazo)-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5417-21-0
dimethyl [benzyl(methyl)amino]propanedioate

: 131843-83-9
Dimethyl 2-(2-Chloro-N-methylacetamido)-2-<2-(2-methoxycarbonyl)phenylazo>malonate

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / H₂ / 10percent Pd/C / methanol / 2.5 h / 20 °C

2: 91 percent / CH₂Cl₂ / 18 h / Heating

3: 1.) 5 M NaNO₂, HOAc, conc. HCl, 2.) aq. K₂CO₃ / 1.) 15 min, 5 deg C, 2.) H₂O, acetone, 1 h, 10 deg C

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; sodium nitrite; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/hlca.19900730615

Reference yield:

: 868-26-8
dimethyl 2-bromomalonate

: 131843-83-9
Dimethyl 2-(2-Chloro-N-methylacetamido)-2-<2-(2-methoxycarbonyl)phenylazo>malonate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 17 h / Ambient temperature

2: 75 percent / H₂ / 10percent Pd/C / methanol / 2.5 h / 20 °C

3: 91 percent / CH₂Cl₂ / 18 h / Heating

4: 1.) 5 M NaNO₂, HOAc, conc. HCl, 2.) aq. K₂CO₃ / 1.) 15 min, 5 deg C, 2.) H₂O, acetone, 1 h, 10 deg C

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; sodium nitrite; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1002/hlca.19900730615

Reference yield:

: 98549-18-9
Dimethyl 2-(Methylamino)malonate Hydrochloride

: 131843-83-9
Dimethyl 2-(2-Chloro-N-methylacetamido)-2-<2-(2-methoxycarbonyl)phenylazo>malonate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / CH₂Cl₂ / 18 h / Heating

2: 1.) 5 M NaNO₂, HOAc, conc. HCl, 2.) aq. K₂CO₃ / 1.) 15 min, 5 deg C, 2.) H₂O, acetone, 1 h, 10 deg C

With hydrogenchloride; potassium carbonate; acetic acid; sodium nitrite; In dichloromethane;
DOI:10.1002/hlca.19900730615