3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile

Base Information

Chemical Name:3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile
CAS No.:1414356-40-3
Molecular Formula:C₂₅H₂₁F₂N₇O₂
Molecular Weight:489.484
Hs Code.:

Synonyms:3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile

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Chemical Property of 3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile

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Technology Process of 3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile

There total 14 articles about 3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3-[4-(2,3-difluorophenoxy)phenyl]-1-[(2R)-pyrrolidin-2-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine bis(trifluoroacetic acid) salt

: 372-09-8
cyanoacetic acid

: 1414356-40-3
3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile

Guidance literature:: With 1,1'-carbonyldiimidazole; In dichloromethane; at 25 ℃; for 12h;

Reference yield:

: 2380-63-4
4-Aminopyrazolo<3,4-d>pyrimidin

: 1414356-40-3
3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 20 - 60 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide / 12.5 h / 25 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 90 °C / Inert atmosphere

4: dichloromethane / 3 h / 25 °C

5: 1,1'-carbonyldiimidazole / dichloromethane / 12 h / 25 °C

With N-iodo-succinimide; di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; 1,1'-carbonyldiimidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1414356-21-0
tert-butyl (2R)-2-([4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidine-1-carboxylate

: 1414356-40-3
3-[(2R)-2-([4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl)pyrrolidin-1-yl]-3-oxopropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 90 °C / Inert atmosphere

2: dichloromethane / 3 h / 25 °C

3: 1,1'-carbonyldiimidazole / dichloromethane / 12 h / 25 °C

With sodium carbonate; 1,1'-carbonyldiimidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water;