2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

Base Information

Chemical Name:2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide
CAS No.:1285515-35-6
Molecular Formula:C₂₃H₂₂F₂N₄O₃
Molecular Weight:440.449
Hs Code.:

Synonyms:2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

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Chemical Property of 2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

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Technology Process of 2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

There total 4 articles about 2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1285514-73-9
2-{[(3,4-difluorophenyl)methyl]oxy}-5-formyl-N-4-pyridazinylbenzamide

: 1285515-35-6
2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

Guidance literature:: morpholine; 2-{[(3,4-difluorophenyl)methyl]oxy}-5-formyl-N-4-pyridazinylbenzamide; With acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 50 ℃;

With sodium hydrogencarbonate; In dichloromethane; 1,2-dichloro-ethane; for 0.166667h;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285515-35-6
2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2.2: pH 1

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 20 °C

4.1: acetic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C

4.2: 50 °C

4.3: 0.17 h

With N-ethylmorpholine;; water; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1285517-24-9
(3,4-difluorophenyl)methyl 2-{[(3,4-difluorophenyl)methyl]oxy}-5-formylbenzoate

: 1285515-35-6
2-{[(3,4-difluorophenyl)methyl]oxy}-5-(4-morpholinylmethyl)-N-4-pyridazinylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

1.2: pH 1

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethylmorpholine; / N,N-dimethyl-formamide / 20 °C

3.1: acetic acid / 1,2-dichloro-ethane / 0.17 h / 20 °C

3.2: 50 °C

3.3: 0.17 h

With N-ethylmorpholine;; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;