5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole

Base Information

Chemical Name:5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole
CAS No.:1307813-82-6
Molecular Formula:C₂₂H₁₃F₅N₂O₃
Molecular Weight:448.349
Hs Code.:

Synonyms:5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole

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Chemical Property of 5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole

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Technology Process of 5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole

There total 10 articles about 5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1307813-81-5
7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)naphtho[1,2-c]isoxazol-5(4H)-one

: 1307813-82-6
5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole

Guidance literature:: With diethylamino-sulfur trifluoride; In 1,2-dichloro-ethane; at 20 - 60 ℃; for 24h;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1307813-82-6
5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.37 h / 0 °C

5.2: 0.58 h / 0 °C

5.3: 20 °C

6.1: tert.-butylhydroperoxide / copper(l) iodide / N,N-dimethyl-formamide; acetonitrile / 20 - 50 °C

7.1: diethylamino-sulfur trifluoride / 1,2-dichloro-ethane / 24 h / 20 - 60 °C

With tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; lithium hydroxide monohydrate; diethylamino-sulfur trifluoride; trifluoroacetic acid; lithium diisopropyl amide; diazomethyl-trimethyl-silane; copper(l) iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 536-74-3
phenylacetylene

: 1307813-82-6
5,5-difluoro-7-methoxy-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-naphtho[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / diethyl ether / 3 h / 20 °C

2.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

4.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

4.2: pH 1

5.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran / 0.37 h / 0 °C

6.2: 0.58 h / 0 °C

6.3: 20 °C

7.1: tert.-butylhydroperoxide / copper(l) iodide / N,N-dimethyl-formamide; acetonitrile / 20 - 50 °C

8.1: diethylamino-sulfur trifluoride / 1,2-dichloro-ethane / 24 h / 20 - 60 °C

With tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; lithium hydroxide monohydrate; diethylamino-sulfur trifluoride; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; diazomethyl-trimethyl-silane; copper(l) iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;