N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Base Information

Chemical Name:N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine
CAS No.:1187669-09-5
Molecular Formula:C₂₀H₂₂N₄OS
Molecular Weight:366.487
Hs Code.:

Synonyms:N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

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Chemical Property of N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Chemical Property:

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Technology Process of N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

There total 7 articles about N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: C₁₇H₁₇N₃O₃S₂

: 1187669-09-5
N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1021/jm901457w

Reference yield:

: 315702-99-9
N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

: 1187669-09-5
N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; water / 1 h / 130 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

3: N,N-dimethyl-formamide / 4 h / 80 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 1187669-09-5
N-(3-methylphenyl)-5-(4-morpholinylmethyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide; bromine; acetic acid / 0 - 75 °C

2.1: ethanol / 3 h / Heating; Reflux

2.2: 2 h / 20 °C / pH ~ 8

3.1: triethylamine / tetrahydrofuran; water / 1 h / 130 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

5.1: N,N-dimethyl-formamide / 4 h / 80 °C

With hydrogen bromide; bromine; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Hantzsch thiazole synthesis;