4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman

Base Information

Chemical Name:4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman
CAS No.:252947-38-9
Molecular Formula:C₃₂H₄₆O₄SSi
Molecular Weight:554.866
Hs Code.:

Synonyms:4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman

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Chemical Property of 4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman

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Technology Process of 4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman

There total 4 articles about 4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

: 209325-02-0
7-Methoxy-3-(4-methoxyphenyl)-3-methylthiochroman-4-one

: 119837-87-5
8-(t-Butyldimethylsilyloxy)-1-octyne

: 252947-38-9
4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; water; ethyl acetate;

Reference yield:

: 4286-55-9
1-bromo-6-hexanol

: 252947-38-9
4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / imidazole / acetonitrile / 24 h / 20 °C

2: 53 percent / dimethylsulfoxide; tetrahydrofuran / 20 °C

3: n-BuLi / tetrahydrofuran; hexane / cooling

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; hexane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmc.2006.03.020

Reference yield:

: 129368-70-3
(6-bromohexyloxy)-tert-butyldimethylsilane

: 252947-38-9
4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / dimethylsulfoxide; tetrahydrofuran / 20 °C

2: n-BuLi / tetrahydrofuran; hexane / cooling

With n-butyllithium; In tetrahydrofuran; hexane; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2006.03.020