(6-BROMOHEXYLOXY)-TERT-BUTYLDIMETHYL-

Base Information

• Chemical Name: (6-BROMOHEXYLOXY)-TERT-BUTYLDIMETHYL-
• CAS No.: 129368-70-3
• Molecular Formula: C12H27BrOSi
• Molecular Weight: 295.335
• Mol file: 129368-70-3.mol

Synonyms:1-t-butyldimethylsilyloxy-6-bromohexane;6-bromo-1-hexanol tert-butyldimethylsilyl ether;6-bromohexyl t-butyldimethylsilyl ether;

Chemical Property of (6-BROMOHEXYLOXY)-TERT-BUTYLDIMETHYL-

Chemical Property:

• Vapor Pressure: 0.00728mmHg at 25°C
• Refractive Index: n20/D 1.4565(lit.)
• Boiling Point: 276oC(lit.)
• Flash Point: >230 °F
• PSA: 9.23000
• Density: 1.053 g/mL at 25oC(lit.)
• LogP: 4.96350

Purity/Quality:

98%,99%, ^*data from raw suppliers

(6-Bromohexyloxy)-tert-butyldimethylsilane 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of (6-BROMOHEXYLOXY)-TERT-BUTYLDIMETHYL-

There total 9 articles about (6-BROMOHEXYLOXY)-TERT-BUTYLDIMETHYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-bromo-6-hexanol (4286-55-9) + tert-butyldimethylsilyl chloride (18162-48-6) → (6-bromohexyloxy)-tert-butyldimethylsilane (129368-70-3)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1246/bcsj.71.1477

Reference yield: 92.4%

1H-imidazole (288-32-4) + 1-bromo-6-hexanol (4286-55-9) + tert-butyldimethylsilyl chloride (18162-48-6) → (6-bromohexyloxy)-tert-butyldimethylsilane (129368-70-3)

Guidance literature:

In tetrahydrofuran;

Reference yield: 84.0%

2,2-dimethylpropionic acid 6-hydroxyhexyl ester (166115-18-0) → (6-bromohexyloxy)-tert-butyldimethylsilane (129368-70-3)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1021/ja5124368

upstream raw materials:

2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran

t-butyldimethylsiyl triflate

1-bromo-6-hexanol

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₄₁H₅₆O₇P₂Si

tert-butyl-(9-(4-methoxyphenyl)nonyloxy)dimethylsilane

((8S)-8-(4-methoxybenzyloxy)-7-hydroxyl-14-(1,3-dithian-2-yl)tetradecyloxy)(tert-butyl)dimethylsilane

(2R,5R)-benzyl 2-(but-3-enyl)-5-(7-(tert-butyldimethylsilyloxy)heptyl)pyrrolidine-1-carboxylate

Refernces

• 1、 Kim,Kee. "A novel method for direct conversion of tetrahydropyranyl ethers into t-butyldimethylsilyl ethers with t-butyldimethylsilyl triflate and dimethyl sulfide". . p. 2899 - 2900. Retrieved 1990.
• 2、 De Baecke, Govert,De Clercq, Pierre J.. "Studies directed towards the total synthesis of (±)-himbacine". . p. 7515 - 7518. Retrieved 1995.
• 3、 -. "Preparation method of alkyl nitrile compound". Paragraph 0101-0103. . Retrieved 2020/05/14.