2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester)

Base Information

Chemical Name:2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester)
CAS No.:123486-02-2
Molecular Formula:C₁₉H₂₂N₄O₇
Molecular Weight:418.406
Hs Code.:

Synonyms:2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester)

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Chemical Property of 2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester)

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Technology Process of 2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester)

There total 4 articles about 2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 108-24-7
acetic anhydride

: 111199-70-3
2-amino-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid bis(ethyl ester)

: 123486-02-2
2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester)

Guidance literature:: With pyridine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jo00286a020

Reference yield:

: 39562-16-8
ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate

: 123486-02-2
2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester)

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / sodium bicarbonate / dimethylformamide / 24 h / 70 °C

2: pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 54 percent / ammonium acetate, NH₃ / tetrahydrofuran / 72 h / Ambient temperature

4: 87 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; ammonium acetate; ammonia; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00286a020

Reference yield:

: 106720-60-9
1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid ethyl ester

: 123486-02-2
2-(acetylamino)-3,6-dihydro-4-methyl-6-(3-nitrophenyl)-1,5(2H)-pyrimidinedicarboxylic acid bis(ethyl ester)

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 54 percent / ammonium acetate, NH₃ / tetrahydrofuran / 72 h / Ambient temperature

3: 87 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; ammonium acetate; ammonia; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00286a020