2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide

Base Information

Chemical Name:2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide
CAS No.:1595289-91-0
Molecular Formula:C₂₆H₂₇N₇O₂
Molecular Weight:469.546
Hs Code.:

Synonyms:2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide

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Chemical Property of 2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide

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Technology Process of 2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide

There total 7 articles about 2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.7%

: 1595291-43-2
tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate

: 1595289-91-0
2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 591-20-8
3-Bromophenol

: 1595289-91-0
2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 4 h / 20 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 100 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

6.1: 1 h / 150 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; cesium fluoride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 19335-11-6
1H-indazol-5-ylamine

: 1595289-91-0
2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol / Reflux

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 12 h / 120 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

4: 1 h / 150 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; In 1,4-dioxane; ethanol; water; butan-1-ol;