tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate

Base Information

• Chemical Name: tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate
• CAS No.: 1595291-43-2
• Molecular Formula: C₃₁H₃₅N₇O₄
• Molecular Weight: 569.663
• Mol file: 1595291-43-2.mol

Synonyms:tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate

Chemical Property of tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate

There total 7 articles about tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

N-(6-chloro-2-(pyrrolidin-1-yl)pyrimidin-4-yl)-1H-indazol-5-amine (1595291-42-1) + N-cyclopropyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetamide (1595290-69-9) → tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate (1595291-43-2)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

3-Bromophenol (591-20-8) → tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate (1595291-43-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 4 h / 20 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 100 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; cesium fluoride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

1H-indazol-5-ylamine (19335-11-6) → tert-butyl 5-(6-(3-(2-(cyclopropylamino)-2-oxoethoxy)phenyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ylamino)-1H-indazole-1-carboxylate (1595291-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / Reflux

2: N-ethyl-N,N-diisopropylamine / butan-1-ol / 12 h / 120 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; In 1,4-dioxane; ethanol; water; butan-1-ol;

upstream raw materials:

3-Bromophenol

N-(6-chloro-2-(pyrrolidin-1-yl)pyrimidin-4-yl)-1H-indazol-5-amine

N-cyclopropyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetamide

1H-indazol-5-ylamine

Downstream raw materials:

2-(3-(6-(1H-indazol-5-ylamino)-2-(pyrrolidin-1-yl)pyrimidin-4-yl)phenoxy)-N-cyclopropylacetamide