N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide

Base Information

• Chemical Name: N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide
• CAS No.: 1244651-57-7
• Molecular Formula: C₁₈H₁₆BrNO₂
• Molecular Weight: 358.235
• Mol file: 1244651-57-7.mol

Synonyms:N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide

Chemical Property of N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide

There total 1 articles about N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(3-bromo-2-iodophenyl)-2-hydroxy-2-methylpropanamide (1244651-37-3) + phenylacetylene (536-74-3) → N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide (1244651-57-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 3.5h; Inert atmosphere;

DOI:10.1039/c004360e

Reference yield: 83.0%

N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide (1244651-57-7) + propargyl alcohol (107-19-7) → 2-hydroxy-N-[3-(3-hydroxyprop-1-yn-1-yl)-2-(phenylethynyl)phenyl]-2-methylpropanamide

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; triethylamine; tri tert-butylphosphoniumtetrafluoroborate; In N,N-dimethyl-formamide; at 60 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.202111267

Reference yield: 83.0%

N-(3-bromo-2-(2-phenylethynyl)phenyl)-2-hydroxy-2-methylpropanamide (1244651-57-7) → 4-bromo-2-phenyl-1H-indole (1244651-87-3)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 140 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c004360e

upstream raw materials:

N-(3-bromo-2-iodophenyl)-2-hydroxy-2-methylpropanamide

phenylacetylene

Downstream raw materials:

4-bromo-2-phenyl-1H-indole

2-phenylbenzo[cd]indole