(2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

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Chemical Name:(2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate
CAS No.:1318249-78-3
Molecular Formula:C₁₈H₂₃NO₃
Molecular Weight:301.386
Hs Code.:

Synonyms:(2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

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Chemical Property of (2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

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Technology Process of (2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

There total 6 articles about (2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2960-66-9
4-oxo-but-2-enoic acid ethyl ester

: N-(4-methylpent-2-enylidene)aniline

: 1318249-78-3
(2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

Guidance literature:: With BF₄^(1-)*C₁₇H₁₇F₅N₃⁽¹⁺⁾; sodium 2-chlorobenzoate; In acrylonitrile; at 0 ℃; for 15h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/ja205714g

Reference yield: 49.0%

: 2960-66-9
4-oxo-but-2-enoic acid ethyl ester

: N-(4-methylpent-2-enylidene)aniline

: (2R,3S)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

: 1318249-78-3
(2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

: ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

Guidance literature:: With BF₄^(1-)*C₁₇H₁₇F₅N₃⁽¹⁺⁾; sodium 2-chlorobenzoate; In dichloromethane; at 0 ℃; for 15h; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/ja205714g

Reference yield:

: 5362-56-1
4-methylpent-2-enal

: 1318249-78-3
(2S,3R)-ethyl 2-((E)-3-methylbut-1-enyl)-5-oxo-1-phenylpyrrolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 12 h / 20 °C / Molecular sieve

2: BF₄^(1-)*C₁₇H₁₇F₅N₃⁽¹⁺⁾; sodium 2-chlorobenzoate / acrylonitrile / 15 h / 0 °C / Molecular sieve; Inert atmosphere

With BF₄^(1-)*C₁₇H₁₇F₅N₃⁽¹⁺⁾; sodium 2-chlorobenzoate; In acrylonitrile;
DOI:10.1021/ja205714g