3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester

Base Information

Chemical Name:3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester
CAS No.:1026049-23-9
Molecular Formula:C₂₃H₂₈N₂O₅S
Molecular Weight:444.552
Hs Code.:

Synonyms:3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester

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Chemical Property of 3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester

Chemical Property:

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Technology Process of 3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester

There total 4 articles about 3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 1026049-23-9
3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

2: 1.) LiHMDS / 1.) THF, RT, 2.) THF, from 0 deg C to RT

3: 100 percent / HCl / ethyl acetate / 0 - 20 °C

4: Et₃N / acetonitrile / 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1021/jm960572n

Reference yield:

: 3-((S)-3-Amino-2-oxo-azepan-1-yl)-propionic acid benzyl ester; hydrochloride

: 1939-99-7
benzenesulfonyl chloride

: 1026049-23-9
3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester

Guidance literature:: With triethylamine; In acetonitrile; at 0 - 20 ℃;
DOI:10.1021/jm960572n

Reference yield:

: 76944-95-1
tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate

: 1026049-23-9
3-((S)-2-Oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LiHMDS / 1.) THF, RT, 2.) THF, from 0 deg C to RT

2: 100 percent / HCl / ethyl acetate / 0 - 20 °C

3: Et₃N / acetonitrile / 0 - 20 °C

With hydrogenchloride; triethylamine; lithium hexamethyldisilazane; In ethyl acetate; acetonitrile;
DOI:10.1021/jm960572n