Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate

Base Information

• Chemical Name: Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate
• CAS No.: 124667-16-9
• Molecular Formula: C₃₁H₂₈N₄O₄S
• Molecular Weight: 552.654

Synonyms:Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate

Chemical Property of Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate

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Technology Process of Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate

There total 2 articles about Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate (94796-13-1) → Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate (124667-16-9)

Guidance literature:

In diethyl ether; dichloromethane; Ambient temperature; 3 - 4h, regioselectivity;

Reference yield: 34.3%

diazomethane (186581-53-3,908094-01-9,334-88-3) + diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate (94796-13-1) → Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate (124667-16-9) + Benzhydryl 7-Phenylacetamido-3-(3'-pyrazolyl)-3,4-(4'',3''-pyrazolino)cepham-4-carboxylate (131330-63-7)

Guidance literature:

In diethyl ether; dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/jhet.5570270521

Reference yield: 87.5%

Diphenylmethyl (6R,7R)-7-phenylacetamido-3-(1-pyrazolin-3-yl)ceph-3-em-4-carboxylate (124667-16-9) → Benzhydryl 7-Phenylacetamido-3-(3'-pyrazolyl)-3-cephem-4-carboxylate 1S-(β)-Oxide (131309-06-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1002/jhet.5570270521

upstream raw materials:

diazomethane

diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate

Downstream raw materials:

Benzhydryl 7-Phenylacetamido-3-(3'-pyrazolyl)-3-cephem-4-carboxylate 1S-(β)-Oxide

Diphenylmethyl (6R,7R)-3-Cyclopropyl-7-phenylacetamidoceph-3-em-4-carboxylate

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