3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole

Base Information

• Chemical Name: 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole
• CAS No.: 14359-34-3
• Molecular Formula: C₂₃H₁₇N₃
• Molecular Weight: 335.408
• Mol file: 14359-34-3.mol

Synonyms:3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole

Chemical Property of 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole

There total 5 articles about 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + benzil (134-81-6) → 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole (14359-34-3)

Guidance literature:

With ammonium acetate; In ethanol; for 0.75h; Reflux; Green chemistry;

DOI:10.1002/aoc.3989

Reference yield: 84.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole (14359-34-3)

Guidance literature:

With copper(l) iodide; ammonium acetate; In butan-1-ol; for 1.08333h; Reflux;

DOI:10.1039/d1ra01767e

Reference yield:

diphenyl acetylene (501-65-5) → 3-(4,5-diphenyl-1H-imidazol-2-yl)-1H-indole (14359-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; dimethyl sulfoxide / 1 h / 130 °C / Green chemistry

2: ammonium acetate / ethanol / 2 h / 100 °C / Green chemistry

With ammonium acetate; iodine; dimethyl sulfoxide; In ethanol;

DOI:10.1002/ejoc.201801584

upstream raw materials:

Indole-3-carboxaldehyde

benzil

diphenyl acetylene

α-iodo-α-phenylacetophenone