2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester

Base Information

Chemical Name:2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester
CAS No.:100044-50-6
Molecular Formula:C₂₄H₃₅NO₆SSi
Molecular Weight:493.697
Hs Code.:

Synonyms:2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester

Suppliers and Price of 2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester

There total 4 articles about 2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82290-86-6
4-acetoxy-3-ethyl-azetidin-2-one

: 100044-50-6
2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / KOH / ethanol; H₂O / 0.5 h

2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 5 min, 2.) THF, from -78 deg C to 0 deg C, 1.5 h

3: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 0.1 h, 2.) THF, RT, 2 h

With potassium hydroxide; lithium hexamethyldisilazane; In ethanol; water;
DOI:10.1021/jo00355a011

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 100044-50-6
2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 5 min, 2.) THF, from -78 deg C to 0 deg C, 1.5 h

2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 0.1 h, 2.) THF, RT, 2 h

With lithium hexamethyldisilazane;
DOI:10.1021/jo00355a011

Reference yield:

: 100044-48-2
(+/-)-4-<((ethoxycarbonyl)methyl)thio>-3-ethyl-2-azetidinone

: 100044-50-6
2-[(2R,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-oxo-azetidin-2-ylsulfanyl]-3-oxo-succinic acid 4-benzyl ester 1-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 5 min, 2.) THF, from -78 deg C to 0 deg C, 1.5 h

2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 0.1 h, 2.) THF, RT, 2 h

With lithium hexamethyldisilazane;
DOI:10.1021/jo00355a011