10-Debc hydrochloride

Base Information

Chemical Name:10-Debc hydrochloride
CAS No.:201788-90-1
Molecular Formula:C₂₀H₂₅ClN₂O
Molecular Weight:344.884
Hs Code.:
DSSTox Substance ID:DTXSID60587887
Pharos Ligand ID:L1F8DSAMLLFS
Mol file:201788-90-1.mol

Synonyms:10-(4'-(N,N-diethylamino)butyl)-2-chlorophenoxazine hydrochloride;10-DEBC hydrochloride

Suppliers and Price of 10-Debc hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
10-DEBC hydrochloride
10mg
$ 409.00

Tocris
10-DEBChydrochloride ≥99%(HPLC)
50
$ 634.00

Tocris
10-DEBChydrochloride ≥99%(HPLC)
10
$ 151.00

American Custom Chemicals Corporation
10-DEBC HYDROCHLORIDE 95.00%
1MG
$ 148.05

AK Scientific
10-Debchydrochloride
50mg
$ 761.00

AK Scientific
10-Debchydrochloride
5mg
$ 229.00

Total 7 raw suppliers

Chemical Property of 10-Debc hydrochloride

Chemical Property:

Vapor Pressure:5.08E-10mmHg at 25°C
Boiling Point:490.9°Cat760mmHg
PKA:10.46±0.25(Predicted)
Flash Point:250.7°C
PSA：15.71000
Density:g/cm³
LogP:6.57280
Storage Temp.:Desiccate at +4°C
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:380.1422188
Heavy Atom Count:25
Complexity:377

Purity/Quality:

99%, ^*data from raw suppliers

10-DEBC hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CCCCN1C2=CC=CC=C2OC3=C1C=C(C=C3)Cl.Cl
Uses 10-DEBC Hydrochloride is an AKT inhibitor. Study shows that efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.

Technology Process of 10-Debc hydrochloride

There total 8 articles about 10-Debc hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 109-89-7
diethylamine

: 201789-01-7
10-(4'-chlorobutyl)-2-chlorophenoxazine

: 201788-90-1
10-[4'-(N-diethylamino)butyl]-2-chlorophenoxazine

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 48h; Heating;

Reference yield:

: 60344-80-1
2-chloro-10H-phenoxazine-10-carboxaldehyde

: 201788-90-1
10-[4'-(N-diethylamino)butyl]-2-chlorophenoxazine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / aq. NaOH; K₂CO₃; CuCO₃ / p-xylene / 2 h / Heating

2: 70 percent / NaNH₂ / liquid ammonia / 2 h

3: 86 percent / KI; K₂CO₃ / acetonitrile / 48 h / Heating

With copper(II) carbonate; sodium hydroxide; potassium carbonate; sodium amide; potassium iodide; In para-xylene; ammonia; acetonitrile; 1: Hydrolysis / 2: Alkylation / 3: Substitution;

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 201788-90-1
10-[4'-(N-diethylamino)butyl]-2-chlorophenoxazine

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / KOH / H₂O / 5 h / 110 - 120 °C

2: 80 percent / Fe; glac. AcOH / H₂O / Heating

3: 2 h / 140 - 160 °C

4: K₂CO₃; CuCO₃ / p-xylene / 36 h / Heating

5: 75 percent / aq. NaOH; K₂CO₃; CuCO₃ / p-xylene / 2 h / Heating

6: 70 percent / NaNH₂ / liquid ammonia / 2 h

7: 86 percent / KI; K₂CO₃ / acetonitrile / 48 h / Heating

With copper(II) carbonate; potassium hydroxide; sodium hydroxide; iron; potassium carbonate; sodium amide; acetic acid; potassium iodide; In para-xylene; ammonia; water; acetonitrile; 1: Condensation / 2: Reduction / 3: Formylation / 4: Cyclization / 5: Hydrolysis / 6: Alkylation / 7: Substitution;