2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one

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Chemical Name:2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one
CAS No.:96252-08-3
Molecular Formula:C₁₆H₁₅N₅O₆
Molecular Weight:373.325
Hs Code.:

Synonyms:2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one

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Chemical Property of 2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one

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Technology Process of 2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one

There total 3 articles about 2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 92-55-7
5-nitro-2-furfuraldehyde diacetate

: 96240-20-9
4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

: 96252-08-3
2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: With hydrogenchloride; In propan-1-ol; for 2h; Heating;
DOI:10.1002/jhet.5570210641

Reference yield:

: 70249-87-5
N⁽¹⁾-Carbethoxyhydrazon von Ethyl-p-methoxybenzoat

: 96252-08-3
2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / butan-1-ol / 30 h / Heating

2: NaH / 1)DMF, room temp., 30 min, 70-80deg C, 2h 2)70-80 deg C, 8h

3: 82 percent / conc. aq. HCl / propan-1-ol / 2 h / Heating

With hydrogenchloride; sodium hydride; hydrazine hydrate; In propan-1-ol; butan-1-ol;
DOI:10.1002/jhet.5570210641

Reference yield:

: 70249-92-2
4-amino-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

: 96252-08-3
2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / 1)DMF, room temp., 30 min, 70-80deg C, 2h 2)70-80 deg C, 8h

2: 82 percent / conc. aq. HCl / propan-1-ol / 2 h / Heating

With hydrogenchloride; sodium hydride; In propan-1-ol;
DOI:10.1002/jhet.5570210641