4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

• Chemical Name: 4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one
• CAS No.: 96240-20-9
• Molecular Formula: C₁₁H₁₄N₄O₃
• Molecular Weight: 250.257

Synonyms:4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

Chemical Property of 4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

Chemical Property:

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Technology Process of 4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

There total 2 articles about 4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N(1)-Carbethoxyhydrazon von Ethyl-p-methoxybenzoat (70249-87-5) → 4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one (96240-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / butan-1-ol / 30 h / Heating

2: NaH / 1)DMF, room temp., 30 min, 70-80deg C, 2h 2)70-80 deg C, 8h

With sodium hydride; hydrazine hydrate; In butan-1-ol;

DOI:10.1002/jhet.5570210641

Reference yield:

4-amino-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one (70249-92-2) + 2-chloro-ethanol (107-07-3) → 4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one (96240-20-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1)DMF, room temp., 30 min, 70-80deg C, 2h 2)70-80 deg C, 8h;

DOI:10.1002/jhet.5570210641

Reference yield: 82.0%

5-nitro-2-furfuraldehyde diacetate (92-55-7) + 4-Amino-2-(2-hydroxy-ethyl)-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one (96240-20-9) → 2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one (96252-08-3)

Guidance literature:

With hydrogenchloride; In propan-1-ol; for 2h; Heating;

DOI:10.1002/jhet.5570210641

upstream raw materials:

4-amino-5-(4-methoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

2-chloro-ethanol

N⁽¹⁾-Carbethoxyhydrazon von Ethyl-p-methoxybenzoat

Downstream raw materials:

2-(2-Hydroxy-ethyl)-5-(4-methoxy-phenyl)-4-{[1-(5-nitro-furan-2-yl)-meth-(Z)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazol-3-one

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