N-benzyloxycarbonyl L-alanine acetoxime ester

Base Information

• Chemical Name: N-benzyloxycarbonyl L-alanine acetoxime ester
• CAS No.: 24125-33-5
• Molecular Formula: C₁₄H₁₈N₂O₄
• Molecular Weight: 278.308
• Mol file: 24125-33-5.mol

Synonyms:N-benzyloxycarbonyl L-alanine acetoxime ester

Chemical Property of N-benzyloxycarbonyl L-alanine acetoxime ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-benzyloxycarbonyl L-alanine acetoxime ester

There total 2 articles about N-benzyloxycarbonyl L-alanine acetoxime ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-Cbz-Ala (1142-20-7) + acetone oxime (127-06-0) → N-benzyloxycarbonyl L-alanine acetoxime ester (24125-33-5)

Guidance literature:

With pyridine; di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1021/op0255938

Reference yield: 82.0%

(N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester (3401-36-3) + acetone oxime (127-06-0) → N-benzyloxycarbonyl L-alanine acetoxime ester (24125-33-5)

Guidance literature:

In chloroform; Ambient temperature;

DOI:10.1016/S0040-4020(01)81345-4

Reference yield:

N-benzyloxycarbonyl L-alanine acetoxime ester (24125-33-5) + ribavirin (36791-04-5,66510-90-5) → C19H23N5O8

Guidance literature:

With lipase Chirazyme L-2; In tetrahydrofuran; at 55 - 60 ℃; for 24h; regioselective reaction; Large scale; Enzymatic reaction;

DOI:10.1021/op0255938

upstream raw materials:

(N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester

acetone oxime

N-Cbz-Ala