acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester

Base Information

• Chemical Name: acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester
• CAS No.: 851714-35-7
• Molecular Formula: C₁₉H₂₁NO₅
• Molecular Weight: 343.379
• Mol file: 851714-35-7.mol

Synonyms:acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester

Chemical Property of acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester

There total 2 articles about acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl trifluoromethanesulfonate (333-27-7) + [(R)-2-hydroxy-2-(4-acetoxy-phenyl)-ethyl]-carbamic acid benzyl ester (851714-32-4) → acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester (851714-35-7)

Guidance literature:

[(R)-2-hydroxy-2-(4-acetoxy-phenyl)-ethyl]-carbamic acid benzyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -74 ℃; for 0.0166667h;

methyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; at -74 ℃; for 1.5h;

DOI:10.1021/ja038043d

Reference yield: 72.0%

→ acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester (851714-35-7)

Guidance literature:

Reference yield: 92.0%

acetic acid 4-(2-benzyloxycarbonylamino-1-(R)-methoxyethyl)phenyl ester (851714-35-7) → [2-(4-hydroxy-phenyl)-2-(R)-methoxy-ethyl]carbamic acid benzyl ester (851714-37-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 23 - 25 ℃; for 1h;

DOI:10.1021/ja038043d

upstream raw materials:

methyl trifluoromethanesulfonate

[(R)-2-hydroxy-2-(4-acetoxy-phenyl)-ethyl]-carbamic acid benzyl ester

Downstream raw materials:

[2-(4-hydroxy-phenyl)-2-(R)-methoxy-ethyl]carbamic acid benzyl ester