methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate

Base Information

Chemical Name:methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate
CAS No.:437718-39-3
Molecular Formula:C₂₁H₂₅N₃O₈S
Molecular Weight:479.511
Hs Code.:

Synonyms:methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate

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Chemical Property of methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate

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Technology Process of methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate

There total 1 articles about methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 240423-09-0
N-(6-aminopropyl)-2-nitrobenzenesulfonamide

: 437718-39-3
methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 5 h / 20 °C

2: 796 mg / Et₃N / CH₂Cl₂ / 2 h / 20 °C

With triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2006.06.051

Reference yield: 85.0%

: 437718-39-3
methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate

: 437718-33-7
7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 0 - 20 ℃; for 1h;
DOI:10.1016/S0960-894X(01)00733-8

Reference yield:

: 437718-39-3
methyl 7-(2-nitrobenzenesulfonylamino)-4-(benzyloxycarbonyl)-4-azaheptanoate

: joramine

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / aq. NaOH / methanol / 1 h / 0 - 20 °C

2: DCC / CH₂Cl₂ / 5 h / 0 °C

3: dimethylformamide / 0.5 h / 20 °C

4: TFA / CHCl₃ / 1 h / 0 - 20 °C

5: Et₃N / dimethylformamide / 2 h / 20 °C

6: 2-mercaptoethanol; DBU / dimethylformamide / 0.5 h / 20 °C

7: H₂; AcOH / Pd(OH)2 / 3 h / 20 °C

With sodium hydroxide; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2-hydroxyethanethiol; palladium dihydroxide; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00733-8