3,4-DICHLORO-5-METHYLPYRROLE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 3,4-DICHLORO-5-METHYLPYRROLE-2-CARBOXYLIC ACID
• CAS No.: 24691-30-3
• Molecular Formula: C6H5Cl2NO2
• Molecular Weight: 194.017
• Hs Code.: 2933990090
• Mol file: 24691-30-3.mol

Synonyms:3,4-Dichloro-5-methyl-1H-pyrrole-2-carboxylic acid;Pyrrole-2-carboxylicacid, 3,4-dichloro-5-methyl- (8CI);

Chemical Property of 3,4-DICHLORO-5-METHYLPYRROLE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 2.5E-06mmHg at 25°C
• Refractive Index: 1.618
• Boiling Point: 376.2 °C at 760 mmHg
• Flash Point: 181.3 °C
• PSA: 53.09000
• Density: 1.61 g/cm³
• LogP: 2.32810

Purity/Quality:

97% ^*data from raw suppliers

3,4-Dichloro-5-methyl-1H-pyrrole-2-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-DICHLORO-5-METHYLPYRROLE-2-CARBOXYLIC ACID

There total 5 articles about 3,4-DICHLORO-5-METHYLPYRROLE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

ethyl 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylate (24691-21-2) → 3,4-di-chloro-5-methyl-1H-pyrrole-2-carboxylic acid (24691-30-3)

Guidance literature:

ethyl 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylate; With methanol; lithium hydroxide; water; In dichloromethane; at 70 ℃; for 2h;

With hydrogenchloride; water; In methanol; dichloromethane; at 0 ℃; for 1h;

Reference yield:

ethyl 5-methyl-1H-pyrrole-2-carboxylate (3284-51-3) → 3,4-di-chloro-5-methyl-1H-pyrrole-2-carboxylic acid (24691-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl dichloride / tetrachloromethane

2: water; sodium hydroxide / methanol

With sulfuryl dichloride; water; sodium hydroxide; In methanol; tetrachloromethane;

DOI:10.1016/j.bmcl.2011.10.010

Reference yield:

2-methyl-1H-pyrrole (636-41-9) → 3,4-di-chloro-5-methyl-1H-pyrrole-2-carboxylic acid (24691-30-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diethyl ether / 2 h

2.1: sodium / 0.5 h / 20 °C

3.1: sulfuryl dichloride / tetrachloromethane / 1.33 h / 0 °C

4.1: lithium hydroxide; water / methanol; dichloromethane / 2 h / 70 °C

4.2: 1 h / 0 °C

With lithium hydroxide; sulfuryl dichloride; water; sodium; In methanol; tetrachloromethane; diethyl ether; dichloromethane;

upstream raw materials:

ethyl 3,4-dichloro-5-methyl-1H-pyrrole-2-carboxylate

ethyl 5-methyl-1H-pyrrole-2-carboxylate

2-methyl-1H-pyrrole

2-pyrrole aldehyde

Downstream raw materials:

ethyl 3-[(1R,5S,6s)-6-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-azabicyclo[3.1.0]hex-3-yl]benzoate

ethyl 4-[(3'-chlorobiphenyl-3-yl)methyl]-2-[(1R,5S,6s)-6-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-3-azabicyclo[3.1.0]hex-3-yl]-1,3-thiazole-5-carboxylate

3,4-dichloro-N-(4-ethynylphenyl)-5-methyl-1H-pyrrole-2-carboxamide

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