3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine

Base Information

• Chemical Name: 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine
• CAS No.: 229343-96-8
• Molecular Formula: C₃₁H₃₆F₃N₆O₈P
• Molecular Weight: 708.631

Synonyms:3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine

Chemical Property of 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine

There total 6 articles about 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phosphoric acid dibenzyl ester (1623-08-1) + 3'-azido-3'-deoxy-N3-{1-[5-(2,2,2-trifluoroacetylamino)pentyl]}thymidine (174571-55-2) → 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N3-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine (229343-96-8)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jo982502p

Reference yield:

2,2,2-trifluoro-N-(5-hydroxypentyl)acetamide (128238-44-8) → 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N3-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine (229343-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 °C

2: 72 percent / potassium carbonate / methanol / 1.5 h / 20 °C

3: 99 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; 1: Substitution / 2: Hydrolysis / 3: Substitution;

DOI:10.1021/jo982502p

Reference yield:

3'-Azido-5'-O-(4-methoxybenzoyl)-3'-deoxythymidine (134077-32-0) → 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N3-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine (229343-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 °C

2: 72 percent / potassium carbonate / methanol / 1.5 h / 20 °C

3: 99 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C

With di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; 1: Substitution / 2: Hydrolysis / 3: Substitution;

DOI:10.1021/jo982502p

upstream raw materials:

phosphoric acid dibenzyl ester

3'-azido-3'-deoxy-N³-{1-[5-(2,2,2-trifluoroacetylamino)pentyl]}thymidine

3'-Azido-5'-O-(4-methoxybenzoyl)-3'-deoxythymidine

2,2,2-trifluoro-N-(5-hydroxypentyl)acetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 229343-96-8 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send