134077-32-0

Upstream product

• 130051-04-6 2,3′-anhydro-5′-O-(4-methoxybenzoyl)thymidine 
• 174571-54-1 3'-azido-3'-deoxy-5'-O-(4-methoxybenzoyl)-N³-{1-[5-(2,2,2,-trifluoroacetylamino)pentyl]}thymidine 
• 50-89-5 thymidine 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 30516-87-1 3'-azido-2',3'-deoxythymidine 
• 182747-96-2 5'-O-(4-methoxybenzoyl)-3'-amino-3'-deoxythymidine 
• 174571-54-1 3'-azido-3'-deoxy-5'-O-(4-methoxybenzoyl)-N³-{1-[5-(2,2,2,-trifluoroacetylamino)pentyl]}thymidine 
• 174571-56-3 3'-azido-3'deoxy-5'-O{[(bis-benzyloxyphosphorylmethyl)benzyloxyphosphorylmethyl]benzyloxyphosphoryl}-N³-{1-[5-(2,2,2-trifluoroacetylamino)pentyl]}thymidine 
• 229343-96-8 3'-azido-3'-deoxy-5'-O-(bis-benzyloxy-phosphoryl)-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine 
• 229343-97-9 3'-azido-3'-deoxy-5'-O-[(bis-benzyloxyphosphorylmethyl)benzyloxyphosphoryl]-N³-{1-[5-(2,2,2-trifluoro-acetylamino)pentyl]}thymidine 
• 195375-41-8 1-[(2R,4S,5S)-5-Hydroxymethyl-4-(trityl-amino)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 195375-40-7 4-Methoxy-benzoic acid (2S,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(trityl-amino)-tetrahydro-furan-2-ylmethyl ester 
• 195375-68-9 3'-NH-trityl-3'-aminothymidine 5'-O-cyanoethyl-N,N-diisopropylaminophosphoramidite 

Relevant academic research and scientific papers

Synthesis of analogues of 5'-mono-, 5'-di-, and 5'-triphosphate-azt for the development of specific enzyme immunoassay for monitoring of intracellular levels of azt-mp, azt-dp, and azt-tp

The synthesis of analogue compounds of polyphosphorylated AZT is described. The compounds are designed to raise specific antibodies against AZT-MP, -DP and -TP in rabbits. Copyright 1999 by Marcel Dekkcr, Inc.

An efficient synthesis of 3'-azido-3'-deoxythymidine (AZT)

A very efficient synthesis of 3'-azido-3'-deoxythymidine (4) (AZT) from thymidine is described. The key step is a one-pot transformation of thymidine into 2,3'-anhydro-5'-O-(4-methoxybenzoyl)-thymidine (2) which is isolated by direct crystallization. Further ring opening of 2 with the azide ion and 5'-O-deprotection afforded AZT in 73% overall yield.