N₁-(4-(dipropylamino)butyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

Base Information

• Chemical Name: N₁-(4-(dipropylamino)butyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride
• CAS No.: 1346804-59-8
• Molecular Formula: C₃₆H₆₁N₅O₅*ClH
• Molecular Weight: 680.372

Synonyms:N₁-(4-(dipropylamino)butyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

Chemical Property of N₁-(4-(dipropylamino)butyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

Chemical Property:

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Technology Process of N₁-(4-(dipropylamino)butyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride

There total 6 articles about N₁-(4-(dipropylamino)butyl)-N₄-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N1-((5S,8S,11S)-5,8-diisobutyl-3,13-dimethyl-4,7,10-trioxo-2-oxa-3,6,9-triazatetradecan-11-yl)-N4-(4-(dipropylamino)butyl)terephthalamide (1346804-56-5) → N1-(4-(dipropylamino)butyl)-N4-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride (1346804-59-8)

Guidance literature:

N₁-((5S,8S,11S)-5,8-diisobutyl-3,13-dimethyl-4,7,10-trioxo-2-oxa-3,6,9-triazatetradecan-11-yl)-N₄-(4-(dipropylamino)butyl)terephthalamide; With lithium aluminium tetrahydride; In diethyl ether; at -80 - 0 ℃; for 1.5h; Inert atmosphere;

With water; In diethyl ether; at 0 ℃; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.07.037

Reference yield:

4-(dipropylamino)butanenitrile → N1-(4-(dipropylamino)butyl)-N4-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride (1346804-59-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 4 h / -78 - 20 °C / Inert atmosphere

2.1: trimethylaluminum / hexane; dichloromethane / 2 h / 0 - 5 °C / Inert atmosphere

2.2: 77 h / 0 °C / Reflux; Inert atmosphere

3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 0 - 20 °C

4.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / -80 - 0 °C / Inert atmosphere

5.2: 0 °C / Inert atmosphere

5.3: Inert atmosphere

With lithium aluminium tetrahydride; lithium hydroxide monohydrate; trimethylaluminum; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;

DOI:10.1016/j.ejmech.2011.07.037

Reference yield:

methyl 4-((4-(dipropylamino)butyl)carbamoyl)benzoate → N1-(4-(dipropylamino)butyl)-N4-((S)-4-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-yl)terephthalamide hydrochloride (1346804-59-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 1 h / 0 - 20 °C

2.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / -80 - 0 °C / Inert atmosphere

3.2: 0 °C / Inert atmosphere

3.3: Inert atmosphere

With lithium aluminium tetrahydride; lithium hydroxide monohydrate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; water;

DOI:10.1016/j.ejmech.2011.07.037

upstream raw materials:

lithium 4-((4-(dipropylamino)butyl)carbamoyl)benzoate

N₁-((5S,8S,11S)-5,8-diisobutyl-3,13-dimethyl-4,7,10-trioxo-2-oxa-3,6,9-triazatetradecan-11-yl)-N₄-(4-(dipropylamino)butyl)terephthalamide

N₁,N₁-dipropylbutane-1,4-diamine

di-n-propylamine

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