toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester

Base Information

• Chemical Name: toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester
• CAS No.: 281658-41-1
• Molecular Formula: C₂₂H₂₁NO₄S
• Molecular Weight: 395.479

Synonyms:toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester

Chemical Property of toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester

Chemical Property:

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Technology Process of toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester

There total 4 articles about toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-phenol (95-55-6) → toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester (281658-41-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 33 percent / K₂CO₃ / acetone / Heating

2: p-toluenesulfonic acid / toluene / Heating

3: LiBH₄

4: pyridine / 20 °C

With pyridine; lithium borohydride; potassium carbonate; toluene-4-sulfonic acid; In acetone; toluene;

DOI:10.1016/j.bmcl.2005.11.054

Reference yield:

ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate (22244-22-0) → toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester (281658-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / toluene / Heating

2: LiBH₄

3: pyridine / 20 °C

With pyridine; lithium borohydride; toluene-4-sulfonic acid; In toluene;

DOI:10.1016/j.bmcl.2005.11.054

Reference yield:

(4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methanol (281658-40-0) + p-toluenesulfonyl chloride (98-59-9) → toluene sulfonic acid 4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl-methyl ester (281658-41-1)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1016/j.bmcl.2005.11.054

upstream raw materials:

(4-phenyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methanol

p-toluenesulfonyl chloride

(+/-)-ethyl 4-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate

2-amino-phenol

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