1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone

Base Information

Chemical Name:1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone
CAS No.:74606-93-2
Molecular Formula:C₂₉H₂₄N₂O₄
Molecular Weight:464.521
Hs Code.:

1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenz<cd>indole-5-propionic acid, γ-lactone

Synonyms:1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone

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Chemical Property of 1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone

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Technology Process of 1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone

There total 6 articles about 1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 74644-93-2
1-benzoyl-4-benzamido-5-oxo-1,2,2a,3,4,5-hexahydrobenzindole

: 17435-72-2
ethyl 2-bromomethyl-2-propenoate

: 74606-93-2
1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone

Guidance literature:: With zinc; iodine; In tetrahydrofuran; at 50 ℃; for 14h;
DOI:10.1021/ja00318a044

Reference yield:

: 74606-98-7
2-benzoylamino-3-(1-benzoyl-2,3-dihydro-indol-3-yl)-propionic acid

: 74606-93-2
1-benzoyl-4-benzamido-1,2,2a,3,4,5-hexahydro-5-hydroxy-α-methylenebenzindole-5-propionic acid, γ-lactone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Ac₂O; 2.) AlCl₃ / 1.) 100 deg C, 15 min; 2.) dichloroethane, reflux, 30 min

2: 83 percent / Zn / I₂ / tetrahydrofuran / 14 h / 50 °C

With aluminium trichloride; acetic anhydride; zinc; iodine; In tetrahydrofuran;
DOI:10.1021/ja00318a044

Reference yield:

: 98-88-4
benzoyl chloride

: 74606-93-2,86783-97-3,88668-86-4
C₂₉H₂₄N₂O₄

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) Ac₂O, 2.) AlCl₃ / 1.) 100 deg C, 15 min, 2.) ClCH₂-ClCH₂, reflux, 30 min

3: 1.) Zn / 2.) THF, 50 deg C, 14 h

With aluminium trichloride; acetic anhydride; zinc;
DOI:10.1021/ja00536a067