4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride

Base Information

• Chemical Name: 4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride
• CAS No.: 1158962-46-9
• Molecular Formula: C₁₃H₂₁NO₂*ClH
• Molecular Weight: 259.776
• Mol file: 1158962-46-9.mol

Synonyms:4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride

Chemical Property of 4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride

There total 1 articles about 4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylmagnesium bromide (925-90-6) + L-tyrosine methyl ester HCl (3417-91-2) → 4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride (1158962-46-9)

Guidance literature:

ethylmagnesium bromide; L-tyrosine methyl ester HCl; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In dichloromethane;

DOI:10.1016/j.tet.2009.03.005

Reference yield: 54.0%

4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride (1158962-46-9) + p-methoxybenzyl chloride (824-94-2) → (S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol (1158962-49-2)

Guidance literature:

4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.tet.2009.03.005

Reference yield: 47.0%

4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride (1158962-46-9) + benzyl chloride (100-44-7) → (S)-2-amino-1-(4-benzyloxyphenyl)-3-ethylpentan-3-ol (1158962-48-1)

Guidance literature:

4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

benzyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.tet.2009.03.005

upstream raw materials:

ethylmagnesium bromide

L-tyrosine methyl ester HCl

Downstream raw materials:

(S)-2-amino-1-(4-benzyloxyphenyl)-3-ethylpentan-3-ol

(S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol