(S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol

Base Information

• Chemical Name: (S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol
• CAS No.: 1158962-49-2
• Molecular Formula: C₂₁H₂₉NO₃
• Molecular Weight: 343.466
• Mol file: 1158962-49-2.mol

Synonyms:(S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol

Chemical Property of (S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol

There total 2 articles about (S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride (1158962-46-9) + p-methoxybenzyl chloride (824-94-2) → (S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol (1158962-49-2)

Guidance literature:

4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.tet.2009.03.005

Reference yield:

C13H21NO2 (1159094-84-4) + p-methoxybenzyl chloride (824-94-2) → (S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol (1158962-49-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.11.022

Reference yield: 79.0%

(S)-1-(4-(4-methoxybenzyloxy)phenyl)-2-amino-3-ethylpentan-3-ol (1158962-49-2) + benzoyl chloride (98-88-4) → N-((S)-1-(4-(4-methoxybenzyloxy)phenyl)-3-ethyl-3-hydroxypentan-2-yl)benzamide (1158962-52-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.03.005

upstream raw materials:

4-[(S)-2-amino-3-ethyl-3-hydroxypentyl]phenol hydrochloride

p-methoxybenzyl chloride

C₁₃H₂₁NO₂

Downstream raw materials:

N-((S)-1-(4-(4-methoxybenzyloxy)phenyl)-3-ethyl-3-hydroxypentan-2-yl)benzamide