4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride

Base Information

• Chemical Name: 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride
• CAS No.: 1221961-81-4
• Molecular Formula: C₁₇H₁₅ClN₂O₂*ClH
• Molecular Weight: 351.232
• Mol file: 1221961-81-4.mol

Synonyms:4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride

Chemical Property of 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride

There total 4 articles about 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoate (1221961-83-6) → 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride (1221961-81-4)

Guidance literature:

With hydrogenchloride; acetic acid; In water; at 100 ℃; for 1h;

Reference yield:

3-(4-chlorophenyl)glutaric anhydride (53911-68-5) → 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride (1221961-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-dioxane / 1 h / 20 °C

2: hydrogenchloride / water / Reflux

3: hydrogenchloride; acetic acid / water / 1 h / 100 °C

With hydrogenchloride; acetic acid; In 1,4-dioxane; water;

Reference yield:

3-(4-chlorophenyl)pentane-1,5-dioic acid (35271-74-0) → 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid monohydrochloride (1221961-81-4)

Guidance literature:

Multi-step reaction with 4 steps

1: acetyl chloride / 2 h / Reflux

2: 1,4-dioxane / 1 h / 20 °C

3: hydrogenchloride / water / Reflux

4: hydrogenchloride; acetic acid / water / 1 h / 100 °C

With hydrogenchloride; acetic acid; acetyl chloride; In 1,4-dioxane; water;

upstream raw materials:

ethyl 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoate

3-(4-chlorophenyl)glutaric anhydride

3-(4-chlorophenyl)pentane-1,5-dioic acid

N-(2-aminophenyl)-3-(4-chlorophenyl)glutaramic acid