Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester

Base Information

Chemical Name:Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester
CAS No.:115047-30-8
Molecular Formula:C₃₃H₄₈O₆Si
Molecular Weight:568.826
Hs Code.:

Synonyms:Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester

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Chemical Property of Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester

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Technology Process of Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester

There total 12 articles about Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115047-28-4,115115-19-0
(3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol

: 115047-30-8
Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 0 deg C, 30 min, 25 deg C, 30 min

2: 1.) ozone, NaHCO₃, 2.) dimethyl sulfide / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, -25 deg C 45 min

With dimethylsulfide; sodium hydrogencarbonate; ozone; methanesulfonyl chloride; triethylamine; In dichloromethane;
DOI:10.1021/ja00224a032

Reference yield:

: 112452-70-7
4(S)-methyl-3(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-5(S)-<1(R)-methyl-1-(2,2,5(S)-trimethyldioxan-4(S)-yl)methyl>dihydro-2(3H)-furanone

: 115047-30-8
Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

2: Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 0 deg C, 30 min, 25 deg C, 30 min

3: 1.) ozone, NaHCO₃, 2.) dimethyl sulfide / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, -25 deg C 45 min

With dimethylsulfide; diisobutylaluminium hydride; sodium hydrogencarbonate; ozone; methanesulfonyl chloride; triethylamine; In hexane; dichloromethane;
DOI:10.1021/ja00224a032

Reference yield:

: 4(S)-methyl-3(S)-(1(S)-methyl-2-hydroxyethyl)-5(S)-<1(R)-methyl-1-(2,2,5(S)-trimethyldioxan-4(S)-yl)methyl>dihydro-2(3H)-furanone

: 115047-30-8
Formic acid (1R,2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2,4-dimethyl-3-oxo-1-[(R)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-pentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / 4-(dimethylamino)pyridine, imidazole / dimethylformamide / 18 h / 25 °C

2: diisobutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

3: Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 0 deg C, 30 min, 25 deg C, 30 min

4: 1.) ozone, NaHCO₃, 2.) dimethyl sulfide / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, -25 deg C 45 min

With 1H-imidazole; dmap; dimethylsulfide; diisobutylaluminium hydride; sodium hydrogencarbonate; ozone; methanesulfonyl chloride; triethylamine; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00224a032