(3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol

Base Information

Chemical Name:(3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol
CAS No.:115047-28-4
Molecular Formula:C₃₃H₅₀O₅Si
Molecular Weight:554.842
Hs Code.:

(3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol

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Chemical Property of (3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol

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Technology Process of (3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol

There total 10 articles about (3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112452-70-7
4(S)-methyl-3(S)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-5(S)-<1(R)-methyl-1-(2,2,5(S)-trimethyldioxan-4(S)-yl)methyl>dihydro-2(3H)-furanone

: 115047-28-4,115115-19-0
(3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1.5h;
DOI:10.1016/S0040-4039(00)95405-4

Reference yield:

: 4(S)-methyl-3(S)-(1(S)-methyl-2-hydroxyethyl)-5(S)-<1(R)-methyl-1-(2,2,5(S)-trimethyldioxan-4(S)-yl)methyl>dihydro-2(3H)-furanone

: 115047-28-4,115115-19-0
(3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 4-(dimethylamino)pyridine, imidazole / dimethylformamide / 18 h / 25 °C

2: diisobutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

With 1H-imidazole; dmap; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00224a032

Reference yield:

: 112452-69-4
4(S)-methyl-3(S)-(1(R),4-dimethyl-2(E)-pentenyl)-5(S)-<1(R)-methyl-1-(2,2,5(S)-trimethyldioxan-4(S)-yl)methyl>dihydro-2(3H)-furanone

: 115047-28-4,115115-19-0
(3S,4S,5S)-3-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-methyl-5-[(S)-1-((4S,5S)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethyl]-tetrahydro-furan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ozone, NaHCO₃, 2.) NaBH₄ / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) MeOH, CH₂Cl₂, -78 deg C, 30 min, 25 deg C, 1 h

2: 87 percent / 4-(dimethylamino)pyridine, imidazole / dimethylformamide / 18 h / 25 °C

3: diisobutylaluminum hydride / CH₂Cl₂; hexane / 1 h / -78 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; diisobutylaluminium hydride; sodium hydrogencarbonate; ozone; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00224a032