4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Base Information

• Chemical Name: 4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide
• CAS No.: 1419221-73-0
• Molecular Formula: C₁₃H₇BrClF₃N₂O
• Molecular Weight: 379.564
• Mol file: 1419221-73-0.mol

Synonyms:4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Chemical Property of 4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide

There total 3 articles about 4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.6%

4-bromo-2-chlorobenzoic acid methyl ester (185312-82-7) + 2-amino-4-(trifluoromethyl)pyridine (106447-97-6) → 4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide (1419221-73-0)

Guidance literature:

4-bromo-2-chlorobenzoic acid methyl ester; With trimethylaluminum; In toluene; at 20 ℃; for 0.166667h; Inert atmosphere;

2-amino-4-(trifluoromethyl)pyridine; In toluene; for 8h; Reflux;

Reference yield:

4-bromo-2-chlorobenzoyl chloride (21900-55-0) + 2-amino-4-(trifluoromethyl)pyridine (106447-97-6) → 4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide (1419221-73-0)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 50 ℃; for 12h;

DOI:10.1021/acsmedchemlett.5b00463

Reference yield:

4-Bromo-2-chloro-benzoic Acid (59748-90-2) → 4-bromo-2-chloro-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide (1419221-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 12 h / 50 °C

With dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acsmedchemlett.5b00463

upstream raw materials:

4-bromo-2-chlorobenzoic acid methyl ester

2-amino-4-(trifluoromethyl)pyridine

4-bromo-2-chlorobenzoyl chloride

4-Bromo-2-chloro-benzoic Acid

Downstream raw materials:

2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide