5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid

Base Information

Chemical Name:5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid
CAS No.:1428548-55-3
Molecular Formula:C₁₉H₁₃F₂N₃O₄
Molecular Weight:385.327
Hs Code.:

Synonyms:5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid

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Chemical Property of 5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid

Chemical Property:

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Technology Process of 5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid

There total 8 articles about 5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428548-54-2
N-[bis(4-fluorophenyl)methyl]-2-formyl-4-hydroxypyrimidine-5-carboxamide

: 1428548-55-3
5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid

Guidance literature:: With sodium chlorite; sodium hydrogenphosphate dodecahydrate; In water; tert-butyl alcohol; at 20 ℃; for 4h;

Reference yield:

: 1428548-41-7
2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxylic acid

: 1428548-55-3
5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; HATU / acetonitrile / 20 °C

2: palladium on activated charcoal; ammonium formate / methanol / Reflux

3: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

4: sodium chlorite; sodium hydrogenphosphate dodecahydrate / water; tert-butyl alcohol / 4 h / 20 °C

With sodium chlorite; sodium hydrogenphosphate dodecahydrate; palladium on activated charcoal; ammonium formate; Dess-Martin periodane; triethylamine; HATU; In methanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 648893-89-4
N-[bis(4-fluorophenyl)methyl]formamide

: 1428548-55-3
5-{[bis(4-fluorophenyl)methyl]carbamoyl}-4-hydroxypyrimidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: water; sodium hydroxide / ethanol / Reflux

2: triethylamine; HATU / acetonitrile / 20 °C

3: palladium on activated charcoal; ammonium formate / methanol / Reflux

4: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

5: sodium chlorite; sodium hydrogenphosphate dodecahydrate / water; tert-butyl alcohol / 4 h / 20 °C

With sodium chlorite; sodium hydrogenphosphate dodecahydrate; palladium on activated charcoal; water; ammonium formate; Dess-Martin periodane; triethylamine; HATU; sodium hydroxide; In methanol; ethanol; dichloromethane; water; acetonitrile; tert-butyl alcohol;