N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide

Base Information

Chemical Name:N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide
CAS No.:1380228-96-5
Molecular Formula:C₂₄H₂₃F₂N₇O₃S
Molecular Weight:527.555
Hs Code.:

Synonyms:N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide

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Chemical Property of N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide

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Technology Process of N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide

There total 21 articles about N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1380228-73-8
2,6-difluoro-N₁-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)benzene-1,3-diamine

: 139631-62-2
cyclopropanesulfonyl chloride

: 1380228-96-5
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 50 ℃; for 2h;

Reference yield:

: 1093101-52-0
6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine

: 1392429-91-2
N-(3-amino-2,4-difluorophenyl)cyclopropanesulfonamide

: 1380228-96-5
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2016.03.055

Reference yield:

: 535170-17-3
tert-butyl (2,6-difluoro-3-nitrophenyl)carbamate

: 1380228-96-5
N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)9H-purin-6-yl)pyridin-2-ylamino)phenyl)cyclopropansulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: palladium on activated charcoal; hydrogen / methanol / 15 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C

3: hydrogenchloride / ethyl acetate; 1,4-dioxane / 5 h / 20 °C

4: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C

5: palladium on activated charcoal; hydrogen / methanol / 1 h

6: pyridine / dichloromethane / 2 h / 50 °C

With pyridine; hydrogenchloride; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;