N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide
• CAS No.: 1030375-04-2
• Molecular Formula: C₁₈H₁₅NO₂S
• Molecular Weight: 309.389
• Mol file: 1030375-04-2.mol

Synonyms:N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide

Chemical Property of N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide

There total 5 articles about N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

propargyl bromide (106-96-7) + 4-methyl-N-(2-((trimethylsilyl)ethynyl)phenyl)benzenesulfonamide (527686-25-5) → N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide (1030375-04-2)

Guidance literature:

With potassium hydroxide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; Sonication;

DOI:10.1002/ejoc.200701038

Reference yield:

propargyl bromide (106-96-7) + N-(2-ethynylphenyl)-4-toluenesulfonamide (497236-62-1) → N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide (1030375-04-2)

Guidance literature:

With potassium carbonate; In acetone; at 60 ℃;

DOI:10.1021/acs.orglett.9b03727

Reference yield:

2-bromoaniline (615-36-1) → N-(2-ethynylphenyl)-4-methyl-N-prop-2-ynylbenzenesulfonamide (1030375-04-2)

Guidance literature:

Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 20 °C / Inert atmosphere; Sealed tube

2: potassium carbonate / methanol / 20 °C / Schlenk technique

3: pyridine; dmap / dichloromethane / 20 °C

4: potassium carbonate / acetone / 60 °C

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In methanol; dichloromethane; acetone;

DOI:10.1021/acs.orglett.9b03727

upstream raw materials:

propargyl bromide

4-methyl-N-(2-((trimethylsilyl)ethynyl)phenyl)benzenesulfonamide

2-bromoaniline

N-(2-ethynylphenyl)-4-toluenesulfonamide

Downstream raw materials:

N-(2-ethynylphenyl)-4-methyl-N-(propa-1,2-dien-1-yl)benzenesulfonamide