1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

Base Information

Chemical Name:1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester
CAS No.:952019-76-0
Molecular Formula:C₂₅H₂₅Cl₂NO₄
Molecular Weight:474.384
Hs Code.:

Synonyms:1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

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Chemical Property of 1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

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Technology Process of 1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

There total 4 articles about 1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 952019-72-6
2-acetyl-3-(4-chlorobenzoyl)succinic acid 4-tert-butyl ester 1-ethyl ester

: 106-47-8
4-chloro-aniline

: 952019-76-0
1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

Guidance literature:: With acetic acid; for 24h; Heating;
DOI:10.1080/00397910701481237

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 952019-76-0
1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

1.2: 100 percent / tetrahydrofuran / 4 h / -78 - 20 °C

2.1: EtONa / ethanol / 0.17 h

2.2: 19 percent / ethanol; toluene / 7 h / 20 °C

3.1: 77 percent / AcOH / 24 h / Heating

With sodium ethanolate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; 3.1: Paal-Knorr cyclization;
DOI:10.1080/00397910701481237

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 952019-76-0
1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole-3,4-dicarboxylic acid 3-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / CH₂Cl₂

2.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

2.2: 100 percent / tetrahydrofuran / 4 h / -78 - 20 °C

3.1: EtONa / ethanol / 0.17 h

3.2: 19 percent / ethanol; toluene / 7 h / 20 °C

4.1: 77 percent / AcOH / 24 h / Heating

With pyridine; sodium ethanolate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; 4.1: Paal-Knorr cyclization;
DOI:10.1080/00397910701481237