2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide

Base Information

Chemical Name:2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide
CAS No.:1312759-99-1
Molecular Formula:C₂₃H₂₂ClF₅N₆O₂
Molecular Weight:544.912
Hs Code.:

Synonyms:2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide

Suppliers and Price of 2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide

There total 4 articles about 2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 950821-44-0
2-(2,4-difluorophenyl)-1-[4-(2-fluoro-4-amino-phenyl)-piperazin-1-yl]-3-(1H-1,2,4-triazol-1-yl)-propan-2-ol

: 76-04-0
2-chloro-2,2-difluoroacetic acid

: 1312759-99-1
2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2011.02.042

Reference yield:

: 154590-33-7
1-(2-fluoro-4-nitrophenyl)piperazine

: 1312759-99-1
2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 5 h / 80 °C

2: hydrazine hydrate / ethanol / 3.5 h / 80 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.042

Reference yield:

: 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[4-(2-fluoro-4-nitrophenyl)piperazin-1-yl]propan-2-ol

: 1312759-99-1
2-chloro-N-(4-(4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]piperazin-1-yl)-3-fluorophenyl)-2,2-difluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3.5 h / 80 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.042